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     About HVRI

Harbin Veterinary Research Institute, CAAS


Director: Kong Xiangang


Address: No. 427 Maduan St. 150001, Harbin, P.R. China

Website: www.hvri.ac.cn


Harbin Veterinary Research Institute (HVRI),subordinated to the Chinese Academy of Agricultural Sciences (CAAS),is located in Harbin, a beautiful and famous cultural city in northeast China. It was founded in June, 1948 as the first veterinary medicine research institute in China.

The institute covers an area of more than 69,600 m2 and possesses a laboratory animal breeding farm with over 1,532,900 min the outskirts of Harbin. To meet the needs of the further development of the institute, it will be relocated to a new site that covers 271,800 m2 with a building area of 145,600 m2.

The institute comprises 566 staffs, including 76 senior researchers. As the doctoral degree authorization institution, HVRI has been authorized to confer master’s degrees and PhD degrees and has awarded 127doctoral degrees and 361 master’s degrees. At present, 210 postgraduates are studying and engaging in researches in the institute.

Objectives and Research Activities

The primary objective of the Harbin Veterinary Research Institute (HVRI), CAAS is to protect the health of husbandry animals, to ensure the security of public health, and to promote scientific and technological developments for the prevention and control of animal infectious diseases.

Research at the HVRI covers international and domestic infectious diseases that affect swine, birds, horses, cattle, and sheep as well as zoonotic and exotic diseases. The institute’s research interests specifically focus on epidemiology, pathogenic mutations, etiology and pathogenesis, technologies for preventing and controlling animal infectious diseases, basic immunobiology and immunology of infectious diseases, and techniques used for the cultivation and quality control of the laboratory animal.

At present, HVRI hosts several national research facilities, such as the State Key Laboratory of Veterinary Biotechnology, the National Reference Laboratory of Avian Influenza, the National Reference Laboratory of Contagious Bovine Pleuropneumonia, and the National Seed Center for Laboratory Avian Animals.

Outstanding Outcomes:

HVRI has developed more than 140 different diagnostic reagents and vaccines, and counts 335 significant scientific advances during its tenure, including numerous vaccines. In 20th century, the institute developed the first successful lentiviral vector-based vaccine, the Donkey leukocyte-attenuated vaccine, which has been widely used to control equine infectious anemia virus. The institute’s attenuated ovinized and caprined rindpest vaccine for cattle and attenuated lapinized bovine pleuropneumonia vaccine were used successfully for the eradication of rinderpest and contagious bovine pleuropneumonia in China. Further, the cooperative advance of attenuated lapinized Chinese strain of hog cholera virus vaccine, is the most extensively adopted vaccine in the world.  In recent years, HVRI has made significant progress studying animal influenza, porcine reproductive and respiratory syndrome (PRRS), and other important epidemic diseases in animals. The first inactivated and attenuated vaccine against PRRS in China was developed at HVRI. In addition, the institute developed the first recombinant avian vaccine, the fowl pox viral vector-based chicken infectious laryngotracheitis vaccine in China. In addition, key proteins essential for trans-species transmission of avian influenza virus have been identified.

Research Unit


Animal influenza research and control team

The animal influenza research and control team conducted confirmative diagnosis of highly pathogenic avian influenza, surveillance and variation analysis of animal influenza viruses, animal influenza vaccine development and update, and development of diagnosis techniques and reagents. Studies were also focused on various aspects of basic research of animal influenza viruses, with emphasis on the molecular basis for virus pathogenesis and transmissibility, virus-host interactions and structure-function study of viral proteins.

Head of Unit: Dr. Chen Hua-Lan (chenhualan@caas.cn)

Avian Immunosuppressive Disease

This group carries out research on avian immunosuppressive diseases: infectious bursal disease virus (IBDV), Marek’s virus (MDV), avian leukosis virus (ALV), reticuloendotheliosis virus (REV), chicken anemia virus (CAV), avian reovirus (ARV). The studies are focused mainly on the pathogenesis, immunosuppressive mechanism, epidemiology and the development of vaccines and diagnostic reagents of these diseases.

Head of Unit: Dr. Wang Xiao-Mei (wangxiaomei@caas.cn)

Avian Respiratory Disease and Immunology

Interest fields focused on important avian viral respiratory diseases such as avian infectious bronchitis (IB), avian Newcastle disease (ND), avian infectious laryngotracheitis (AILT) and related vaccine development. The unit also carried out research on major or emerging viral diseases of waterfowl, such as avian Tembusu viral disease, duck viral hepatitis and duck viral enteritis.

Head of Unit: Dr Liu Sheng-Wang(liushengwang@caas.cn)

Zoonosis and Exotic Disease

The mission of zoonosis and exotic disease is to build up scientific knowledge and technical resources thus providing support the prevention and control of emerging and re-emerging zoonosis, and transboundary animal infectious diseases, including brucella, rabies, blue tongue disease, peste des petits ruminants, African swine fever, Rift valley fever, Nipah encephalitis, Japanese encephalitis, West Nile encephalitis, vesicular stomatitis, and so on.

Head of Unit: Dr. Bu Zhi-Gao (buzhigao@caas.cn)

Zoonosis of Natural Foci

Isolation and epidemiological surveillance techniques are developed to the pathogen/antibody for diseases on wild animals and insect-borne. The biological characteristics and cross-species transmission mechanisms of zoonosis are focus on paramyxoviridae, and parvoviridae etc. The molecular mechanisms of infection and immunity are related to calicivirus and pasteurella multocida. The prevention and control strategys of natural foci zoonosis are developed.

Head of Unit: Dr. Qu Lian-Dong (quliandong@caas.cn)

Basic Immunology Team:

Our studies relate to innate intracellular immunity by understanding how host cellular factors inhibit pathogen replication. In particular, we are interested to study natural host factors that have the ability to inhibit pathogen replication. Understanding the activity of these restriction factors has permitted the discovery of novel anti- pathogen mechanisms, and holds the great promise of new therapies.

Head of the team: Dr. Zheng Yong-Hui (zhengyo@msu.edu)

Fatal Viral Diseases of Swine

This unit carries out basic as well as translational research on several serious viral diseases of swine, such as classical swine fever, African swine fever, Aujeszky is disease and swine vesicular disease.

Head of Unit: Dr. Qiu Hua-Ji (qiuhuaji@caas.cn)

Swine Digestive System Infectious Disease

The studies are focused on important pathogeny of porcine digestive system infectious diseases such as Transmissible gastroenteritis virus(TGEV),Porcine epidemic diarrhea virus(PEDV) ,Porcine rotavirus(PoRV), Porcine enterovirus virus(PEV), or other diseases: Porcine circovirus 2(PCV2), and Porcine parvovirus(PPV) and Porcine teschovirus (PTV).

Head of Unit: Dr.Feng Li (fengli@caas.cn)

Animal Bacterial Diseases

The studies focus on animal bacterial diseases including epidemiology, multi-antibiotic resistance, molecular pathogenesis, comparative genomics, important protein structure & function, and genetic engineering vaccine & diagnostic techniques of animal bacterial pathogens, such as Mycobacterium bovis, Mycoplasma bovis, Escherichia coli, Salmonella and Actinobacillus pleuropneumoniae.

Head of Unit: Dr. Liu Si-Guo (liusiguo@caas.cn)

Livestock Infectious Diseases

This unit focuses on etiology, epidemiology, molecular mechanisms of pathogenesis and novel vaccines against livestock diseases. Viruses and bacteria currently being studied include FMDV, BVDV, IBRV, BPI3V, BRV, BTV, AKAV,BRV, Pasteurella multocida type A,and Clostridium perfringens.

Head of Unit: Dr Yu Li (yuli02@caas.cn)

Equine Infectious Diseases and Lentivirus Infection

This unit works on the important equine viral diseases, including equine infectious anemia, equine influenza, equine arteritis, and equine rhinopneumonitis.  The researches are focus on epidemiology and immunology of above diseases. An equine infectious anemia virus vaccine model is used to study the mechanism of protective immunity for lentiviruses. This unit is an OIE reference laboratory for equine infectious anemia.

Head of Unit: Dr. Wang Xiao-Jun (wangxiaojun@caas.cn)

Animal Diseases Surveillance and Molecular Epidemiology

(Animal pathogen surveillance and molecular epidemiological studies)

This unit carries out research on the genetic variation and molecular epidemiology of animal important pathogen, pathogenic and infection mechanism of emerging virus, and early warning technology of emerging infectious diseases. Studies are also conducted on the interaction between high pathogenic pathogen and its host. The studies are focused on important viral porcine diseases such as emerging diseases: PRRS, PCV2, and Aujeszky’s diseases. 

Head of Unit: Dr Cai Xue-Hui (caixuehui@caas.cn)

Laboratory Animal and Comparative Medicine

The laboratory Animal and Comparative Medicine unit mainly studies the sciences related with the breading and quality control system as well as application of high quality laboratory animals, especially of specific pathogen-free chickens, ducks and minipigs, currently focuses on the host basic immunity& genetics mechanism of disease resistance and comparative medicine and the various detection techniques of laboratory animals. Meanwhile the unit manages to build technique platform and diseases infection models of genetically modified animals.

Head of Unit: Dr Chen Hong-Yan (chenhongyan@caas.cn)



    There are 5000 m of laboratories, which are confined laboratories for vaccination and infection challenges.

Experimental confined facilities for Avain ( including hens ducks pigeon):

--- 150 m2; experimental section consisting of about 150 isolators.

Experimental confined facilities for Pigs and sheep:

--- 800 m2, 6 containment experimental rooms.

Experimental confined facilities for Rodent:

--- 150 m2, including different sized IVCs (about 480 cages) for rats, mice, cavia porcellus and mink, to study vaccination and infection challenges.

Experimental confined facilities for rabbits:

--- 75 m2, including 2 IVCs (about 24 cages)and 48 containers,to study vaccination and infection challenges .

Experimental confined facilities for dogs:

--- 250 m2, 10 containment experimental rooms to study vaccination and infection challenges.


International cooperation and partners:

Currently, HVRI is the host institute for the World Organization for Animal Health (OIE) Collaborating Center for Zoonoses of Asia-Pacific, the Food and Agriculture Organization Reference Center for Animal Influenza, the OIE Reference Laboratory for Avian Influenza, and the OIE Reference Laboratory for Equine Infectious Anemia. In 2013, the Joint Center for Innate Immunity was established by HVRI and College of Veterinary Medicine of Michigan State University.

Through international cooperation, HVRI has established a stable extensive cooperative system by cooperating with international partners, and gradually formed a favorable international collaboration and information exchange platform. In order to promote substantial cooperation, and vigorously strived for international cooperation projects from a variety of routes, HVRI has signed twelve memoranda of understanding with international partner.  From 2005, a total fund of nearly 4 million US dollars has been awarded to 15 international cooperation projects with U.S., Japan, Australia, and Canada, FAO and other countries and regions.


Contact: Zhang Jing

Email: zj@hvri.ac.cn

Tel: +86 189-4606-6220

Fax: +86 451-51997166

Address: No. 427 Maduan St. 150001, Harbin, P.R. China

Website: www.hvri.ac.cn

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