中国农业科学院哈尔滨兽医研究所

哈兽研阐明结核分枝杆菌PE_PGRS23蛋白抑制巨噬细胞自噬促进病原菌胞内存活的机制

研究进展

03-29 Hongyang Liu, Jimin Yu , Guangqiang Ye, Jiaxiu Gao, Li Huang, Zhaoxia Zhang, Changjiang Weng. E3 ubiquitin ligase Stub1 enhances viral replication by promoting TBK1 degradation through molecular chaperone-mediated autophagy .Cell Death Differ. doi：10.1038/s41418-026-01716-7
03-29 Jun Wang #, Jitao Chang # , Zhigang Jiang #, Hechun Deng, Qi Jia, Kuanhao Li, Jiangang Zhao, Haoyu Xiang, Fan Yang, Songkang Qin, Yuxin Han, Binxin Yao, Fang Wang, Xin Yin, Dongbo Sun. An oral rotavirus-vectored vaccine confers protection against Clostridium perfringens and rotavirus .J Virol. doi：10.1128/jvi.00178-26
03-29 Yudi Pan, Jiapei Huang, Longjun Guo, Zixin Li, Hongyan Shi, Yanxiang Zhou, Jianshuang Cui, Hailiang Ge, Li Feng, Jin Tian. CLDN3 inhibits rotavirus attachment by targeting residue 74 of VP7 .PLoS Pathog. doi：10.1371/journal.ppat.1014045
03-29 He Zhang, Yang Wu, Haojie Wang, Tianxu Liu, Xing Liu, Jianxing Chen, Yue Sun, Lihong Xue, Changwen Li, Huairan Liu, Hongyan Chen, Yinglin Qi, Tongqing An, Liang Wang, Zhimin Jin , Changqing Yu , Xinyue Yang, Yuebao Li, Hui Li , Changyou Xia, Xin Yin, Lin Wang. Experimental hepatitis E virus genotype 1 infection in three types of wild rodents .PLoS Pathog. doi：10.1371/journal.ppat.1014050
03-29 Tingting Feng, Zhenjun Zhang, Hui Wang, Xinxin Zang, Jiajun Zhang, Yanyan Jiang, Yingying Cui, Yifan Duan, Ruonan Guo, Yunjie Gao, Chunwen Chen, Guanghui Dang, Siguo Liu. PE_PGRS23 promotes intracellular survival of Mycobacterium tuberculosis by competitively regulating autophagy gene expression through TFEB and USF2 .J Immunol. doi：10.1093/jimmun/vkag029
03-29 Guangyi Liu, Xiaoyang Zhao, Yuezhi Lin, Xiaojun Wang, Diqiu Liu. A Comparative Review of Veterinary and Human Vaccine Development Strategies: Insights into Herpesvirus Vaccinology from Latency to Elimination .Vaccines (Basel). doi：10.3390/vaccines14030249
03-29 Jingzhe Han, Mengmeng Huang, Guodong Wang, Yulong Zhang, Runhang Liu, Hangbo Yu, Ziwen Wu, Erjing Ke, Dan Ling, Suyan Wang, Yuntong Chen, Yongzhen Liu, Yanping Zhang, Hongyu Cui, Yulu Duan, Liuan Li, Yulong Gao, Xiaole Qi. Identification of a Novel Antigenic Epitope in Envelope Protein of Avian Reticuloendotheliosis Virus .Vet Sci. doi：10.3390/vetsci13030263
03-29 Dan Zang, Wuchang Heng, Ruiyu Li, Chenxi Wei, Ruibin Qi, Getachew Mulatu Dilba, Jiasen Liu, Qian Jiang , Honglin Jia , Hongtao Kang. Feline calicivirus VP1-based mRNA vaccine protects cats against FCV challenge .Virol Sin. doi：10.1016/j.virs.2026.03.010

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