Dandan Ye , Zhaoyang Ji , Hongyan Shi , Jianfei Chen , Da Shi , Liyan Cao , Jianbo Liu , Mingwei Li , Hui Dong , Zhaoyang Jing , Xiaobo Wang , Qiuge Liu , Qianjin Fan, Guangyi Cong , Jiyu Zhang , Yuru Han, Jiyong Zhou , Jinyan Gu, Xin Zhang, Li Feng 

Arch Virol. 2020 Aug 5. doi: 10.1007/s00705-020-04712-5. Online ahead of print.

Abstract

Mammalian orthoreoviruses (MRVs) infect almost all mammals, and there are some reports on MRVs in China. In this study, a novel strain was identified, which was designated as HLJYC2017. The results of genetic analysis showed that MRV HLJYC2017 is a reassortant strain. According to biological information analysis, different serotypes of MRV contain specific amino acid insertions and deletions in the σ1 protein. Neutralizing antibody epitope analysis revealed partial cross-protection among MRV1, MRV2, and MRV3 isolates from China. L3 gene recombination in MRV was identified for the first time in this study. The results of this study provide valuable information on MRV reassortment and evolution.