1、个人简历

姜丽，女，博士，中国农业科学院哈尔滨兽医研究所动物流感基础与防控研究创新团队，研究员。2007年毕业于中国科学院遗传与发育生物学研究所并获得理学博士学位，自2008年起在美国威斯康星大学麦迪逊主校区医学院从事重要疾病相关的生物大分子结构与功能研究。2012年加入中国农业科学院哈尔滨兽医研究所动物流感基础与防控研究团队，主要从事流感病毒与宿主互作的相关基础研究工作。

2、联系方式

电话：0451-51051759

邮箱：jiangli@caas.cn

通讯地址：黑龙江省哈尔滨市香坊区哈平路678号

3、工作经历

2019.1-今  中国农科院哈尔滨兽医研究所  研究员

2012.11-2018.12  中国农科院哈尔滨兽医研究所  副研究员

2008.05-2012.10  威斯康星大学医学院  研究助理及博士后

4、承担主要科研项目

1. 科技部十四五重点研发计划项目，2024YFE0198700，新发禽流感病毒跨种感染和致病机制研究，2024/9-2027/8，377.55万元，主持

2. 黑龙江省自然科学基金杰青项目，JQ2023C006，流感病毒核糖核蛋白复合体VRNP与宿主互作研究，2023/7-2026/7，50万元，主持

3. 国家自然科学基金面上项目，32172847，宿主蛋白ABTB1调控流感病毒复制的分子机理，2022/1-2025/12，58万元，主持

4. 国家自然科学基金面上项目，31672582，宿主蛋白与流感病毒NP蛋白互作及调控病毒复制机制研究，2017/1-2020/12，61万元，主持

5. 国家自然科学基金创新研究群体科学基金，31521005，动物传染病，2016/1-2021/12，1200万元， 参与

5、代表性研究论文   

1. Guangwen Wang, Li Jiang, Jinliang Wang, Qibing Li, Jie Zhang, Fandi Kong, Ya Yan, Yuqin Wang, Guohua Deng, Jianzhong Shi, Guobin Tian, Xianying Zeng, Liling Liu, Zhigao Bu, Hualan Chen, Chengjun Li. Genome-wide siRNA library screening identifies human host factors that influence the replication of the highly pathogenic H5N1 influenza virus. mLife. 2025 Feb 24;4(1):55-69. doi: 10.1002/mlf2.12168.

2. Yuzhen Hu, Li Jiang, Guangwen Wang, Yangming Song, Zhibo Shan, Xuyuan Wang, Guohua Deng, Jianzhong Shi, Guobin Tian, Xianying Zeng, Liling Liu, Hualan Chen, Chengjun Li. M6PR interacts with the HA2 subunit of influenza A virus to facilitate the fusion of viral and endosomal membranes. Sci China Life Sci. 2024 Mar;67(3):579-595. doi: 10.1007/s11427-023-2471-4.  

3. Wenjun Shi , Zhibo Shan , Li Jiang , Guangwen Wang, Xuyuan Wang, Yu Chang, Yuzhen Hu, Bo Wang, Qibing Li, Yihan Wang, Guohua Deng, Jianzhong Shi, Yongping Jiang, Xianying Zeng, Guobin Tian, Hualan Chen, Chengjun Li. ABTB1 facilitates the replication of influenza A virus by counteracting TRIM4-mediated degradation of viral NP protein. Emerg Microbes Infect. 2023 Dec;12(2):2270073. doi: 10.1080/22221751.2023.2270073.  Epub 2023 Nov 2.

4. Li Jiang, Hualan Chen, Chengjun Li. Advances in deciphering the interactions between viral proteins of influenza A virus and host cellular proteins. Cell Insight. 2023 Jan 31;2(2):100079. doi: 10.1016/j.cellin.2023.100079.

5. Junping Li, Libin Liang, Li Jiang, Qian Wang, Xia Wen, Yuhui Zhao, Pengfei Cui, Yaping Zhang, Guangwen Wang, Qibing Li, Guohua Deng, Jianzhong Shi, Guobin Tian, Xianying Zeng, Yongping Jiang, Liling Liu, Hualan Chen, Chengjun Li. Viral RNA-binding ability conferred by SUMOylation at PB1 K612 of influenza A virus is essential for viral pathogenesis and transmission PLoS Pathog. . 2021 Feb 11;17(2):e1009336. doi: 10.1371/journal.ppat.1009336.

6. Nan Sun, Li Jiang, Miaomiao Ye, Yihan Wang, Guangwen Wang, Xiaopeng Wan, Yuhui Zhao, Xia Wen, Libin Liang, Shujie Ma, Liling Liu, Zhigao Bu, Hualan Chen, Chengjun Li. TRIM35 mediates protection against influenza infection by activating TRAF3 and degrading viral PB2. Protein Cell. 2020 Dec;11(12):894-914. doi: 10.1007/s13238-020-00734-6.

7. Libin Liang, Li Jiang, Junping Li, Qingqing Zhao, Jinguang Wang, Xijun He, Shanyu Huang, Qian Wang, Yuhui Zhao, Guangwen Wang, Nan Sun, Guohua Deng, Jianzhong Shi, Guobin Tian, Xianying Zeng, Yongping Jiang, Liling Liu, Jinxiong Liu, Pucheng Chen, Zhigao Bu, Yoshihiro Kawaoka, Hualan Chen, Chengjun Li. Low Polymerase Activity Attributed to PA Drives the Acquisition of the PB2 E627K Mutation of H7N9 Avian Influenza Virus in Mammals. mBio. 2019 Jun 18;10(3):e01162-19. doi: 10.1128/mBio.01162-19.

8. Weiyu Luo, Jie Zhang, Libin Liang, Guangwen Wang, Qibing Li, Pengyang Zhu, Yuan Zhou, Junping Li, Yuhui Zhao, Nan Sun, Shanyu Huang, Chenchen Zhou, Yu Chang, Pengfei Cui, Pucheng Chen, Yongping Jiang, Guohua Deng, Zhigao Bu, Chengjun Li, Li Jiang, Hualan Chen. Phospholipid scramblase 1 interacts with influenza A virus NP, impairing its nuclear import and thereby suppressing virus replication. PLoS Pathog. 2018 Jan 19;14(1):e1006851. doi: 10.1371/journal.ppat.1006851.

9. Seung-Hyeon Seok, Woojong Lee, Li Jiang, Kaivalya Molugu, Aiping Zheng, Yitong Li, Sanghyun Park, Christopher A Bradfield, Yongna Xing. Structural hierarchy controlling dimerization and target DNA recognition in the AHR transcriptional complex. Proc Natl Acad Sci U S A. 2017 May 23;114(21):5431-5436. doi: 10.1073/pnas.1617035114.  Epub 2017 Apr 10.

10. Li Jiang, Vitali Stanevich, Kenneth A Satyshur, Mei Kong, Guy R Watkins, Brian E Wadzinski, Rituparna Sengupta, Yongna Xing. Structural basis of protein phosphatase 2A stable latency. Nat Commun. 2013:4:1699. doi: 10.1038/ncomms2663.