1、个人简历

李明蔚，女，博士/助理研究员，猪消化道传染病创新团队在站博士后。主要从事猪肠道冠状病毒致病机制的研究。近年在PLoSPathogens、 Journal of Virology和Frontiers in veterinary science等杂志共发表9篇。

2、联系方式

研究方向：兽医微生物及其分子生物学

电话：0451-51051881

邮箱：limingwei101825@163.com

通讯地址：黑龙江省哈尔滨市南岗区哈平路678号

3、教育经历

2012.09-2017.06 西北农林科技大学 动物医学专业  学士

2017.09-2020.06 中国农业科学院哈尔滨兽医研究所 预防兽医  硕士

2020.09-2023.6 中国农业科学院哈尔滨兽医研究所 预防兽医 博士

4、工作经历

2023.08-至今  中国农业科学院哈尔滨兽医研究所  助理研究员

5、代表性论文与著作

1. Li, M., Y. Wu, J. Chen, H. Shi, Z. Ji, X. Zhang, D. Shi, J. Liu, J. Tian, X. Wang, Z. Shi, H. Zhang, H. Zhang, L. Guo and L. Feng (2022). "Innate Immune Evasion of Porcine Epidemic Diarrhea Virus through Degradation of the FBXW7 Protein via the Ubiquitin-Proteasome Pathway." J Virol 96(5): e0088921. 

2. Wu, Y., M. Li, J. Tian, H. Yan, Y. Pan, H. Shi, D. Shi, J. Chen, L. Guo and L. Feng (2023). "Broad antagonism of coronaviruses nsp5 to evade the host antiviral responses by cleaving POLDIP3." PLoS Pathog 19(10): e1011702.

3. Li, M., L. Guo and L. Feng (2022). "Interplay between swine enteric coronaviruses and host innate immune." Front Vet Sci 9: 1083605.

4. Wu, Y., Y. Wang, X. Wang, M. Li, H. Yan, H. Shi, D. Shi, J. Chen, L. Guo and L. Feng (2024). "Elevation of IL-8 secretion induced by PEDV infection via NF-κB signaling pathway." Front Cell Infect Microbiol 14: 1422560.

5. Wu, Y., Z. Shi, J. Chen, H. Zhang, M. Li, Y. Zhao, H. Shi, D. Shi, L. Guo and L. Feng (2022). "Porcine deltacoronavirus E protein induces interleukin-8 production via NF-κB and AP-1 activation." Vet Microbiol 274: 109553.

6. Ji, Z., D. Shi, H. Shi, X. Wang, J. Chen, J. Liu, D. Ye, Z. Jing, Q. Liu, Q. Fan, M. Li, G. Cong, J. Zhang, Y. Han, X. Zhang and L. Feng (2021). "A porcine epidemic diarrhea virus strain with distinct characteristics of four amino acid insertion in the COE region of spike protein." Vet Microbiol 253: 108955.

7. Wu, Y., H. Zhang, J. Chen, Z. Shi, M. Li, Y. Zhao, H. Shi, D. Shi, L. Guo and L. Feng (2022). "Stromal Antigen 2 Deficiency Induces Interferon Responses and Restricts Porcine Deltacoronavirus Infection." Viruses 14(8).

8. Wu, Y., H. Zhang, Z. Shi, J. Chen, M. Li, H. Shi, D. Shi, L. Guo and L. Feng (2020). "Porcine Epidemic Diarrhea Virus nsp15 Antagonizes Interferon Signaling by RNA Degradation of TBK1 and IRF3." Viruses 12(6).

9. Ye, D., Z. Ji, H. Shi, J. Chen, D. Shi, L. Cao, J. Liu, M. Li, H. Dong, Z. Jing, X. Wang, Q. Liu, Q. Fan, G. Cong, J. Zhang, Y. Han, J. Zhou, J. Gu, X. Zhang and L. Feng (2020). "Molecular characterization of an emerging reassortant mammalian orthoreovirus in China." Arch Virol 165(10): 2367-2372.