Home      |      About us      |      Administration      |      Research      |      Scientist      |      Research Progress      |      Int’l cooperation      |      News      |      Join us
Location: home» News» New Papers
Novel genotype of infectious bronchitis virus isolated in China. Vet Microbiol. 2019 Mar;230:178-186

Ma T , Xu L , Ren M , Shen J , Han Z , Sun J , Zhao Y , Liu S .

Vet Microbiol. 2019 Mar;230:178-186. doi: 10.1016/j.vetmic.2019.01.020. Epub 2019 Jan 29.



Recombination events are known to contribute to the emergence of novel infectious bronchitis virus (IBV) genotypes. In this study, we carried out detailed phylogenetic analysis and sequence comparisons based on 74 complete nucleotide sequences of the IBV S1 gene, including strain I0636/16 and 73 representative sequences from each genotype and lineage. The results showed that strain I0636/16 represented a novel genotype, designated as lineage 1 within genotype VII (GVII-1). Further comparative genomic analysis revealed at least two recombination sites that replaced the spike gene in a lineage 18 within genotype I (GI-18)-like virus with an as-yet-unidentified sequence, likely derived from another IBV strain, resulting a novel serotype with a lower affinity to the respiratory tract in chickens. To the best of our knowledge, this provides the first evidence for recombination leading to replacement of the complete spike gene and the emergence of a novel genotype/serotype with a lower affinity to the respiratory tract in chickens comparing to one of its parental virus ck/CH/LGX/111119. These results emphasize the importance of limiting exposure to novel IBVs that may serve as a source of genetic material for emerging viruses, as well as the importance of IBV surveillance in chicken flocks.

Previous: The Nrf2 pathway is required for intracellular replication of Toxoplasma gondii in activated macrophages.Parasite Immunol. 2019 Feb 27:e12621
Next: Novel variant strains of infectious bursal disease virus isolated in China. Vet Microbiol. 2019 Mar;230:212-220
COPYRIGHT (C) 2015 HVRI.AC.CN ALL RIGHTS RESERVED 技术支持:中国农业科学院农业信息研究所 ICP:05001785